Chlorogenic acid suppresses interleukin-1β-induced inflammatory mediators in human chondrocytes

International Journal of Clinical and Experimental Pathology

Li-Dong Wu¹  Wei-Ping Chen¹ 

关键词: Chlorogenic acid;    inducible NO synthase;    cyclooxygenase;    chondrocyte;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

We investigated the anti-inflammatory properties of chlorogenic acid (CGA) in interleukin-1β-induced chondrocytes. The nitric oxide (NO) and prostaglandin E2 (PGE₂) were detected by Griess and Enzyme-linked immunosorbent assay (ELISA) respectively. Quantitative real-time PCR and western blot were performed to measure the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2. Our results indicate that CGA inhibited the production of NO and PGE₂ as well as the expression of iNOS and COX-2 in chondrocytes. Our data suggest that CGA possess potential value in the treatment of OA.

【 授权许可】

Unknown