Ectopic expression of AP-2α transcription factor suppresses glioma progression

International Journal of Clinical and Experimental Pathology

Jing Gong¹  Miao Xu¹  Ni Chen¹  Xinglan Li¹  Ling Nie¹  Qiao Zhou¹  Xueqin Chen¹  Juan Xia¹  Wenjing Su¹ 

关键词: AP-2 alpha;    glioma;    cell growth;    apoptosis;    invasion;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

The transcriptional factor AP-2α is a tumor suppressor gene and is downregulated in various neoplasms including glioma. Although the level of AP-2α is negatively associated with the grade of human glioma, the specific functions of AP-2α in glioma are still unknown. In this study, we experimentally showed that artificial overexpression of AP-2α in glioma T98G and U251 cells significantly downregulated the mRNA levels of Bcl-xl, Bcl-2, c-IAP2 and survivin, together with upregulation of the Hrk mRNA levels. Reintroduction of AP-2α also induced downregulation of the protein levels of survivin and VEGF in glioma cells. In biological assays with T98G and U251 cells, AP-2α reduced tumor cell growth, increased cell death, attenuated cell migration and endothelial tube formation. The AP-2α transcription factor may play an important role in suppressing glioma progression.

【 授权许可】

Unknown