Clinical significance of TMPRSS4 in prostate cancer

International Journal of Clinical and Experimental Pathology

Yijun Shen¹  Linguo Wen¹  Dingwei Ye¹  Xiaoqun Yang¹  Xiaojian Qin¹  Wenjun Xiao¹  Guohai Shi¹  Bo Dai¹  Yao Zhu¹  Chunguang Ma¹  Yiping Zhu¹  Hailiang Zhang¹  Dalong Cao¹ 

关键词: Transmembrane protease;    serine 4;    prostatic cancer;    prognosis;    biomarker;    neoadjuvant chemotherapy;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Transmembrane protease serine 4 (TMPRSS4) is a type-II transmembrane serine protease that plays an important role in the migration of cancer cells. This study aimed to investigate both the expression of TMPRSS4 and its clinical significance in prostate cancer. The expression of TMPRSS4 was evaluated in 73 pairs of prostate cancer and adjacent non-cancerous tissues by immunohistochemistry. The level of TMPRSS4 in prostate cancer tissues was significantly higher than that in adjacent non-cancerous tissues. High TMPRSS4 expression was significantly associated with advanced TNM stage and LNM. No association between TMPRSS4 expression and progression-free survival was observed in all patients. Stratified analyses according to clinical features revealed that patients with low TMPRSS4 expression had poor prognosis compared with those with high TMPRSS4 expression in subjects not receiving neoadjuvant chemotherapy. In conclusion, TMPRSS4 showed abnormal expression in prostate cancer tissues. TMPRSS4 may be a potential prognostic biomarker for prostate cancer patients who did not undergo neoadjuvant chemotherapy.

【 授权许可】

Unknown