Increased expression of miR-24 is associated with acute myeloid leukemia with t(8;21)

International Journal of Clinical and Experimental Pathology

Xiao-Wen Zhu¹  Jing-Dong Zhou¹  Zhao-Qun Deng¹  Jia-Yu Yin¹  Xiang-Mei Wen¹  Wei Qian¹  Jun Qian¹  Jiang Lin¹  Qin Tang¹  Ying-Ying Zhang¹ 

关键词: miR-24;    acute myeloid leukemia;    microRNA;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

This study was designed to learn the expression status of miR-24 and its clinical relevance in patients with acute myeloid leukemia (AML). We detected the miR-24 expression levels using real-time quantitative PCR in 84 AML patients and investigated the clinical significance of miR-24 expression in AML. There was no difference in clinical parameters between cases with miR-24 high expression and with miR-24 low expression. The frequency of miR-24 high expression was higher in patients with t(8;21) than in others (82% (9/11) versus 44% (32/72), P=0.026). The levels of miR-24 expression had no correlation with the mutations of nine genes (FLT3-ITD, NPM1, C-KIT, IDH1/IDH2, DNMT3A, N/K-RAS and C/EBPA). Meanwhile, among the group who obtained CR, the cases with miR-24 high expression had no difference in overall survival (OS) and relapse-free survival (RFS) than those with miR-24 low expression (P=0.612 and 0.665, respectively). These findings implicated that miR-24 high regulation is a common event in AML with t(8;21), and it might serve as a novel and selective therapeutic target for the treatment of AML with t(8;21).

【 授权许可】

Unknown