Parotid gland follicular lymphoma lacking both cytoplasmic and surface light chains: a rare case

International Journal of Clinical and Experimental Pathology

Jenny Smith¹  Jeffrey Cao¹  Xiangdong Xu¹  Fang Wen¹ 

关键词: Follicular lymphoma;    immunoglobulin light chain;    parotid gland;    flow cytometry;    light chain negativity;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Immunoglobulin light chain (LC) restriction is detected in the majority of B-cell non-Hodgkin lymphoma (B-NHL) by flow cytometric immunophenotyping (FCI) and serves as a surrogate marker of monoclonality. Even though it is known a small percentage of mature B-NHLs lacking surface LC, deficiency of both cytoplasmic and surface LCs has been reported in only three B-NHL cases. We report a primary parotid gland follicular lymphoma in a 63-year-old man and the lymphoma cells were deficient of cytoplasmic/surface LCs. Compared to previous reports, we used a more sensitive FCI method by combining both monoclonal and polyclonal anti-LC antibodies. Lacking LCs poses as a pitfall for the initial diagnosis of B-NHL, as well as for detecting minimal residual disease. It is important to be aware of this rare immunophenotypic aberrancy.

【 授权许可】

Unknown