Long noncoding RNA GHET1 promotes the development of bladder cancer

International Journal of Clinical and Experimental Pathology

Wen-Shuo Bao¹  Da-Ke Chen¹  Lin-Jin Li¹  Wei-Wen Huang¹  Jian-Long Zhu¹  Zhi-Liang Weng¹ 

关键词: Long noncoding RNA;    bladder cancer;    GHET1;    prognosis;    proliferation;    epithelial-mesenchymal-transition;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and prognostic marker of bladder cancer. A growing volume of literature has implicated the vital role of long noncoding RNA in the development of cancer. GHET1, a recently identified lncRNA, was initially characterized in gastric cancer. However, its role in bladder cancer remains largely unknown. In this study, we demonstrated that GHET1 was upregulated in bladder cancer tissues compared to adjacent normal tissues and its over-expression correlates with tumor size, advanced tumor and lymph node status, and poor survival. GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro. In the meantime, inhibition of GHET1 reversed the epithelial-mesenchymal-transition in bladder cancer cell line. Taken together, our study suggests that the potential use of GHET1 as a prognostic marker and therapeutic target of bladder cancer.

【 授权许可】

Unknown