International Journal of Clinical and Experimental Pathology | |
Assessing the role of IL-35 in colorectal cancer progression and prognosis | |
Bin Kong1  Long He1  Wan-Dang Wang1  Bin-Hua Wu1  Tian-Yu Li1  Wen-Yu Xiang1  Jun-Fa Xu1  Jun-Ai Zhang1  Shu Zhang1  Zhi Zhang1  Yan-Fang Liang1  Jin-Cheng Zeng1  Jing-Jing Bao1  Zhi-Yong Wang1  Xiao-Dong Chen1  Cong-Yi Wang1  Hong-Mei Wang1  | |
关键词: Interleukin-35; colorectal cancer; regulatory T cell; EBI3; IL-12p35; | |
DOI : | |
学科分类:生理学与病理学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Despite the recent realization of Interleukin (IL)-35 in tumorigenesis, its exact impact on colorectal cancer (CRC) progression and prognosis, however, is yet to be elucidated clearly. We thus in the present report conducted comparative analysis of IL-35 levels between CRC patients and matched control subjects. IL-35 is highly expressed in all CRC tissues, which can be detected in vast majority of colorectal cancer cells. IL-35 levels in CRC lysates and serum samples are highly correlated to the severity of malignancy and the clinical stage of tumor. Particularly, a significant reduction for serum IL-35 was noted in patients after surgical resection, indicating that IL-35 promotes CRC progression associated with poor prognosis. Mechanistic study demonstrated a significant correlation between serum IL-35 levels and the number of peripheral regulatory T (Treg) cells in CRC patients, suggesting that IL-35 implicates in CRC pathogenesis probably by inducing Treg cells, while cancer cell-derived IL-35 may also recruit Treg cells into the tumor microenvironment in favor of tumor growth. Together, our data support that IL-35 could be a valuable biomarker for assessing CRC progression and prognosis in clinical settings.
【 授权许可】
Unknown
【 预 览 】
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RO201912140866774ZK.pdf | 1785KB | download |