Secretory meningiomas: clinical, radiological and pathological findings in 70 consecutive cases at one institution

International Journal of Clinical and Experimental Pathology

Hong-Da Zhu¹  Ying Mao¹  Ping Zhong¹  Hai-Liang Tang¹  Xian-Cheng Chen¹  Kang Zheng¹  Liang-Fu Zhou¹  Dai-Jun Wang¹  Yin Wang¹  Wei-Min Bao¹  Li-Qian Xie¹  Hai-Xia Cheng¹  Qing Xie¹  Yong-Fei Wang¹  Bo-Jie Yang¹  Hong Chen¹  Ming-Zhe Zheng¹  Ye Gong¹  Feng-Ping Huang¹ 

关键词: Location;    prognosis;    radiology;    secretory meningiomas;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Secretory meningioma (SM) is a rare, benign subtype of meningioma. Between January 2005 and December 2010, 70 SMs were operated on at the Department of Neurosurgery, Huashan Hospital, Fudan University. We retrospectively analyzed the clinical data, radiological and immunohistochemical findings, and patient outcome to discuss the specific features of SMs. Cranial base preference, hyper-signal in T2 weighted MR image, “xenon light” gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) enhancement were frequently observed in the 70 cases. Non-skull base SMs, which received more complete resection (p<0.01) and had better short-term and long-term outcome, were observed with more severe peritumoral brain edema (PTBE) (p<0.001). In follow-up, only 1 cranial base SM case showed tumor progression. 3 cases died after operation, all with cranial base SMs. As for the 10 cases given Simpson grade 3 or 4 resection who were available at follow-up, 3 died, 5 received gamma-knife therapy, and the other 2 cases received no treatment at all. Only one of the 2 residual SMs without postoperative radiation presented minor progression at a median of 48 months follow-up. In conclusion, cranial base preference, hyper-signal T2 weighted MR image and “xenon light” GD-DTPA enhancement are specific for SMs. Prognosis of SMs is related with operation completeness and surgical risks, rather than the extent of PTBE. Residual SM grows slowly and reacts well to gamma-knife therapy.

【 授权许可】

Unknown