Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells

International Journal of Clinical and Experimental Pathology

Si-Nan Sun¹  Hao Chen¹  Ji-Hai Yu¹  Wei-Dong Jia¹  Jin-Liang Ma¹  Yong-Sheng Ge¹  Jian-Sheng Li¹ 

关键词: Docosahexaenoic (DHA);    Bcl-2;    caspase-3;    MMP-9;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

The docosahexaenoic (DHA), a ω-3 fatty acid, could play a beneficial inhibition of the incidence and progress of a series of human diseases including cancer. It has been report that DHA is involved in cell apoptosis. Recent studies show that the signal transduction pathway links with bcl-2, bax, caspase-3 and MMP-9 molecules. Therefore, we tested the relationship between DHA and cell apoptosis in human hepatocellular carcinoma cells (Bel-7402 cells). We show here that DHA induces Bel-7402 cells apoptosis after pre-treating cells with DHA. DHA down-regulates the protein expression of Bcl-2 and Bim mRNA level, and up-regulates caspase-3 activity and Bax expression level. We also found that DHA inhibits Bel-7402 cells migration. Basic on our studies, DHA may play a role in tumor invasion and survival.

【 授权许可】

Unknown