Double-hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature

International Journal of Clinical and Experimental Pathology

Ling Zhang¹  Lynn C Moscinski¹  Peter Papenhausen¹  Stuart Schwartz¹  Haipeng Shao¹  Elizabeth M Sagatys¹  Reza Setoodeh¹ 

关键词: Mantle cell lymphoma;    double hit lymphoma;    MYC;    8q24;    translocation;    amplification;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Mature B-cell lymphomas with both BCL2 and MYC translocations are known as “double hit” lymphomas. These lymphomas are aggressive and show high proliferation rate due to the growth advantages provided by MYC and BCL2 translocation and overexpression. Mantle cell lymphoma (MCL) is a neoplasm of mature B-lymphocytes with characteristic t(11;14) and subsequent Cyclin D1 overexpression. Secondary cytogenetic changes are frequent in MCL, but MYC translocation has only been rarely reported. In this study, we report four cases of MCL with MYC translocation or MYC gene amplification detected by conventional cytogenetics, fluorescence in situ hybridization and whole genome single nucleotide polymorphism (SNP) array, and determined the clinicopathologic features. Our study provides further evidence supporting the concept of “double hit” MCL with co-involvement of MYC gene rearrangement and/or amplification and CCND1 gene rearrangement.

【 授权许可】

Unknown