CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease

International Journal of Clinical and Experimental Pathology

Haixia Zhou¹  Yulin Feng¹  Bo Wang¹  Jing Yang¹  Xuemei Ou¹  Lijing Deng¹  Lan Wang¹  Jun Xiao¹ 

关键词: CTLA-4;    chronic obstructive pulmonary disease;    polymorphisms;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population. Methods: Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods. Results: We found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease. Conclusion: Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility in a Chinese population.

【 授权许可】

Unknown