Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma cell myeloma

International Journal of Clinical and Experimental Pathology

Shouying Du¹  Huan-You Wang¹  H Elizabeth Broome¹  Thomas J Kipps¹  Hooman H Rashidi¹  Dzung T Le¹ 

关键词: Chronic lymphocytic leukemia;    systemic mastocytosis;    systemic mastocytosis with associated clonal haematological non-mast cell lineage disease;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease (SM-AHNMD) is a heterogeous group of mast cell disorders with different clinical, pathologic and underlying molecular characteristics. While myelomonocytic/myeloid neoplasia overwhelmingly predominates the AHNMD component, lymphoproliferative disorders rarely occur as an AHNMD component of SM-AHNMD. Here we report two cases of SM-AHNMD, in which the AHNMD component is chronic lymphocytic leukemia in one case, and concurrent chronic lymphocytic leukemia as well as plasma cell myeloma in another case. To the best of our knowledge, this is the first case report of SM-AHNMD with chronic lymphocytic leukemia and plasma cell dyscrasia simultaneously.

【 授权许可】

Unknown