The Role of T Cells in Osteoporosis, an Update

International Journal of Clinical and Experimental Pathology

Xudong Huang¹  Wen Zhao¹  Wenlu Yang¹  Jack T. Rogers¹  Yuying Liu¹  Catherine M. Cahill¹ 

关键词: Osteoporosis;    T cells;    osteoclast;    osteoclastogenesis;    cytokine;    chemokine;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Emerging evidence highlights the importance of the interplay between the bone and immune systems. That evidence bolsters a longstanding recognition that estrogen deficiency, infection, inflammation, and autoimmune disorders are associated with systemic and local bone loss. Yet, only recently has an understanding emerged that T lymphocytes and their products act as key regulators of osteoclast formation, life span, and activity. This review presents this understanding of the process of T lymphocytes and their products mediating osteoporosis and explores some of the most recent findings and hypotheses to explain their action in bone. A more complete appreciation of the interactions between immune and bone cells should lead to targeted therapeutic strategies for diseases that affect either or both systems.

【 授权许可】

Unknown