Fibrosing Cholestatic Hepatitis: Clinicopathologic Spectrum, Diagnosis and Pathogenesis

International Journal of Clinical and Experimental Pathology

Liang Lu¹  Hanlin L. Wang¹  Shu-Yuan Xiao¹ 

关键词: Viral hepatitis;    hepatitis B virus;    hepatitis C virus;    liver transplantation;    pathogenesis;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive, sometimes fatal form of liver injury. Though originally reported in liver transplant recipients with recurrent hepatitis B, it has now been recognized frequently in chronic hepatitis B or C patients who are under immunosuppression. The histopathologic hallmarks in the liver include marked hepatocytic injury, severe cholestasis, and periportal and pericellular fibrosis. The pathogenesis is largely unknown. The aim of this review is to describe the spectrum of clinical conditions in which FCH occurs, common histopathologic findings, features unique to certain underlying diseases, factors to be considered in differential diagnosis, and our current understanding of pathogenesis of this disease.

【 授权许可】

Unknown