International Journal of Clinical and Experimental Pathology | |
The Clinical Significance of Massive Intratumoral Lymphocytosis in Squamous Cell Carcinoma of the Anus | |
Per J Nilsson1  Fredrik Petersson1  Ander Höög1  Harald Blegen1  Runjan Chetty1  Carlos A Rubio1  | |
关键词: Squamous cell carcinoma; anal canal; intratumoral lymphocytes; | |
DOI : | |
学科分类:生理学与病理学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
A recent report indicates that patients with squamous cell carcinoma of the anal canal (SCCAC) and intraepithelial lymphocytes have a poor prognosis. Against that background, histological sections from 277 consecutive SCCACs were reviewed searching for cases with massive tumor-infiltrating lymphocytes (TILs; ≥ 50 lymphocytes /100 tumor cells). Of the 277 SCCACs, 8 (3%) had massive TILs. These 8 patients (all females) had both more advanced clinical stage than the remaining 269 control SCCAC patients. Follow-up studies revealed that the 8 patients with SCCACs having massive TILs had a much better 15 years survival rate than control SCCAC patients. It is concluded that despite SCCAC patients with massive TILs had a more advanced clinical stage than SCCAC controls, SCCAC with massive TILs patients had a longer survival rate (with no deaths after 5 years) than control cases. The search via proteomic methodology for the lymphocyte-attracting tumor protein might bring forward a novel co-adjuvant therapy, capable to increase prolonged survival time in patients having SCCAC without massive TILs.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912140866006ZK.pdf | 317KB | download |