C-MYC Rearrangements are Frequent in Aggressive Mature B-Cell Lymphoma with Atypical Morphology

International Journal of Clinical and Experimental Pathology

Xianfeng F Zhao¹  Arie Perry¹  Anjum Hassan¹  Sanford A Stass¹  Louis P Dehner¹  Yi Ning¹ 

关键词: Aggressive mature B-cell lymphoma;    Burkitt lymphoma;    diffuse large B-cell lymphoma;    grey zone lymphoma;    C-MYC rearrangement;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Diagnosis and classification of aggressive mature B-cell lymphoma with atypical morphology remains a challenge. To identify factors that may contribute to the atypical morphology, we selected eight such cases and evaluated their morphologic, immunophenotypic and cytogenetic features and clinical outcomes. The neoplastic cells showed a diffuse monotonous infiltrating pattern with a spectrum of morphology including: 1) L1 lymphoblastic; 2) centroblastic; 3) immunoblastic; and 4) mixed centroblastic and immunoblastic. The lymphoma cells in most cases were positive for CD10 and/or BCL6, and showed BCL2 expression. 6 of 8 cases showed C-MYC rearrangements, and interestingly, all 6 cases demonstrated a proliferation index of ≤90%. 3 of the 6 cases also demonstrated t(14;18). Clinical follow-up indicated that aggressive mature B-cell lymphoma may benefit from more intensified chemotherapeutic regimens used for BL. Our study suggests that aggressive mature B-cell lymphoma with atypical morphology may be another “grey zone lymphoma” lying in the spectrum between Burkitt lymphoma and diffuse large B-cell lymphoma.

【 授权许可】

Unknown