Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney

American Journal of Translational Research

Zhen-Xian Du¹  Hua-Qin Wang¹  Jia-Ning Miao¹  Feng Du¹  Si Li¹  De-Tian Li¹  Tian Wang¹  Hai-Yan Zhang¹  Zhi-Hong Zong¹  Xiao-Hui Bian¹  Bo Liu¹ 

关键词: BAG3;    Cordyceps sinensis;    unilateral ureteral obstruction;    renal fibrosis;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

BAG3 regulates a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, and epithelial-mesenchymal transition (EMT). However, the role of BAG3 in renal tubular EMT and renal interstitial fibrosis remains elusive. This study aimed to examine the dynamic expression of BAG3 during renal fibrosis, and to investigate the efficacy of Cordyceps sinensis (C. sinensis) on renal fibrosis. A rat model of unilateral ureteral obstruction (UUO) was established, and the expression of BAG3 and α-SMA, and the efficacy of C. sinensis on renal fibrosis induced by UUO were examined. The results showed that UUO led to collagen accumulation, which was significantly suppressed by C. sinensis. UUO increased the expression of BAG3 and α-SMA, a mesenchymal marker, while UUO induced BAG3 and α-SMA expression was significantly inhibited by C. sinensis. In addition, immunohistochemical staining demonstrated that BAG3 immunoreactivity was restricted to tubular epithelium. In conclusion, BAG3 is a potential target for the prevention and/or treatment of renal fibrosis, and C. Sinensis is a promising agent for renal fibrosis.

【 授权许可】

Unknown