Cytokine networking of chondrocyte dedifferentiation in vitro and its implications for cell-based cartilage therapy

American Journal of Translational Research

Yujie Liang¹  Jielin Chen¹  Bin Ma¹  Mingtao Li¹  Li Duan¹  Weimin Zhu¹  Daping Wang¹ 

关键词: Chondrocyte dedifferentiation;    in vitro;    cytokines;    signaling pathways;    cartilage repair;    autologous chondrocyte implantation;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Autologous chondrocyte implantation (ACI) is a golden treatment for large defects of the knee joint without osteoarthritis or other complications. Despite notable progresses, generation of a stable chondrocyte phenotype using progenitor cells remains a main obstacle for chondrocyte-based cartilage treatment. Monolayer chondrocyte expansion in vitro is accompanied by chondrocyte dedifferentiation, which produces a non-specific mechanically inferior extracellular matrix (ECM) unsuitable for ACI. In-depth understanding of the molecular events during chondrocyte dedifferentiation is required to maintain the capacity of in vitro expanded chondrocytes to produce hyaline cartilage-specific ECM. This review discusses key cytokines and signaling pathways involved in chondrocyte dedifferentiation from the standpoint of catabolism and anabolism. Some potential therapeutic strategies are also presented to counteract chondrocyte dedifferentiation for cell-based cartilage therapy.

【 授权许可】

Unknown