Arg16Gly and Gln27Glu β2 adrenergic polymorphisms influence cardiac autonomic modulation and baroreflex sensitivity in healthy young Brazilians

American Journal of Translational Research

Bruno Rodrigues¹  Alessandra Goulart¹  Grazia M Guerra¹  Priscila R Mello¹  Magda M Atala¹  Dulce E Casarine¹  Cristiano Mostarda¹  Maria-Claudia Irigoyen¹  Fernanda M Consolim-Colombo¹  Alexandre C Pereira¹ 

关键词: β2-adrenergic polymorphism;    autonomic nervous system;    cardiac autonomic balance;    heart rate variability;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

The association between functional β₂ adrenergic receptor (β₂-AR) polymorphisms and cardiac autonomic modulation is still unclear. Thus, two common polymorphisms in the β₂-AR gene (Gln27Glu β₂ and Arg16Gly β₂) were studied to determine whether they might affect tonic and reflex cardiac sympathetic activity in healthy young subjects. A total of 213 healthy young white subjects of both genders (53% female), aged 18-30 years (23.5±3.4 y), had their continuous blood pressure curves noninvasively recorded by Finometer at baseline, and other hemodynamic parameters, as cardiac autonomic modulation, baroreflex sensitivity, and allele, genotype, and diplotype frequencies calculated. Associations were made between Arg16Gly β₂ and Gln27Glu β₂ polymorphisms and between β₂-AR diplotypes and all variables. The heart rate was significantly lower (P<0.001) in the presence of homozygous Arg/Arg alleles (60.9±1.5 bpm) than in that of Arg/Gly heterozygotes (65.9±1.0 bpm) or Gly/Gly homozygotes (66.3±1.2 bpm). Homozygous carriers of Arg16 allele had an alpha index (19.2±1.3) significantly higher (P<0.001) than that of the subjects with the Gly allele Gly/Gly (14.5±0.7) or Arg/Gly (14.6±0.7). Furthermore, the recessive Glu27Glu and the heterozygous Gln27Glu genotypes had a higher percentage of low-frequency components (LF%) than the homozygous Gln27Gln (15.1% vs. 16.0% vs. 8.2%, P=0.03, respectively). In healthy young subjects, the presence of β₂-AR Arg16 allele in a recessive model was associated with higher baroreflex sensitivity, and increased parasympathetic modulation in studied individuals.

【 授权许可】

Unknown