Characterization of surgical models of postoperative tumor recurrence for preclinical adjuvant therapy assessment

American Journal of Translational Research

Louis A Aliperti¹  Olugbenga T Okusanya¹  Aaron Blouin¹  Veena Kapoor¹  Sunil Singhal¹  Jarrod D Predina¹  Brendan Judy¹  Daniel Levine¹  Zvi G Fridlender¹  Jon Quatromoni¹ 

关键词: Surgery;    recurrence;    models;    surgical oncology;    concomitant immunity;    perioperative immunosuppression;    TGF-β;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Nearly 30% of cancer patients undergoing curative surgery succumb to distant recurrent disease. Despite large implications and known differences between primary and recurrent tumors, preclinical adjuvant therapy evaluation frequently occurs only in primary tumors and not recurrent tumors. We hypothesized that well characterized and reproducible models of postoperative systemic recurrences should be used for preclinical evaluation of adjuvant approaches.

【 授权许可】

Unknown