American Journal of Translational Research | |
CD133, Trop-2 and α2β1 integrin surface receptors as markers of putative human prostate cancer stem cells | |
Lucia R Languino1  Saverio Alberti1  Jing Li1  Marco Trerotola1  Swati Rathore1  Hira Lal Goel1  Dave Adams1  Zhong Jiang1  Mauro Piantelli1  | |
关键词: Prostate cancer; cancer stem cells; CD133; Trop-2; α2β1 integrin; immunohistochemistry; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Cancer stem cells (CSCs) play a key role in initiation and development of cancer and are attractive targets for therapy. The identification of CSC surface receptors to be used as therapeutic targets in vivo remains a difficult task. In this study, we assessed the expression pattern of three surface receptors: CD133, Trop-2 and α2β1 integrin in human prostate cancer in order to identify CSC-niches. CD133 was found to be expressed in small clusters of cells localized in focal areas of benign as well as malignant lesions, suggesting that this protein is a bona fide marker of the prostate stem/progenitor compartment. Trop-2 was localized in both basal and luminal layers of benign glands and was highly expressed in malignant lesions. Moreover, isolated cells in benign and malignant areas were found to co-express both CD133 and Trop-2. α2β1 integrin was expressed in the prostatic epithelium as well as in the surrounding stroma, limiting its utility as a marker of CSCs. In summary, we demonstrate that the combination of CD133 and Trop-2 is useful to mark putative CSC-containing compartments in human prostate.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912140865635ZK.pdf | 311KB | download |