Modulation of NFAT-5, an outlying member of the NFAT family, in human keratinocytes and skin

American Journal of Translational Research

John Afolayan¹  Bernhard Zelger¹  Wael I Al-Daraji¹  Adel Abdellaoui¹  Bettina G Zelger¹ 

关键词: Cyclosporin A (CsA);    Human keratinocytes;    Hypertonicity;    NFAT-5 (TonEBP);    psoriasis;    UVR;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Cyclosporin A (CsA) and tacrolimus block T cell activation by inhibiting the phosphatase calcineurin and preventing translocation from the cytoplasm to the nucleus of the transcription factor Nuclear Factor of Activated T cells (NFAT). NFAT compose a family of transcription factors that are turned on during T cell activation.

【 授权许可】

Unknown