Citrate metabolism in blood transfusions and its relationship due to metabolic alkalosis and respiratory acidosis

International Journal of Clinical and Experimental Medicine

Kai Li¹  Yuan Xu¹ 

关键词: Citrate metabolism;    metabolic alkalosis;    respiratory acidosis;    electrolyte imbalance;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Metabolic alkalosis commonly results from excessive hydrochloric acid (HCl), potassium (K⁺) and water (H₂O) loss from the stomach or through the urine. The plasma anion gap increases in non-hypoproteinemic metabolic alkalosis due to an increased negative charge equivalent on albumin and the free ionized calcium (Ca⁺⁺) content of plasma decreases. The mean citrate load in all patients was 8740±7027 mg from 6937±6603 mL of transfused blood products. The citrate load was significantly higher in patients with alkalosis (9164±4870 vs. 7809±3967, P < 0.05). The estimated mean total citrate administered via blood and blood products was calculated as 43.2±34.19 mg/kilogram/day. In non-massive and frequent blood transfusions, the elevated carbon dioxide output has been shown to occur. Due to citrate metabolism causes intracellular acidosis. As a result of intracellular acidosis compensation, decompensated metabolic alkalosis + respiratory acidosis and electrolyte imbalance may develop, blood transfusions may result in certain complications.

【 授权许可】

Unknown