Polyethylene-oxide improves microcirculatory blood flow in a murine hemorrhagic shock model

International Journal of Clinical and Experimental Medicine

Min Feng¹  Huijuan Shi¹  Yuan Tian¹  Siyuan Chang¹  Daqian Xu¹ 

关键词: PEO;    multiple organ dysfunctions;    hemorrhagic shock;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Background: Polyethylene oxide (PEO) is a synthetic polymer commonly used in medicine production to reduce toxicity. In the present study, we assessed whether PEO can have a functional effect on improving microcirculatory blood flow after hemorrhagic shock in an animal model. Methods: Hemorrhagic shock (HS) was introduced in 78 C57BL/6 mice, which were then equally divided into two groups. One group of mice was intravenously injected with PEO (diluted in Ringer’s solution (RS), PH = 7.4), and the other with RS only. The parameters of microcirculatory hemodynamics, arterial blood gas analysis and multi-organ functions were compared between two groups, 0, 3, 12 and 24 hours after resuscitation. Results: After HS, the hemodynamics, including microvascular diameter, red blood cell velocity, and blood flow rates were significantly improved in time-dependent manners in PEO treated mice. Most parameters of arterial blood gas analysis, except PCO₂, were also significantly improved by PEO. Multi-organ immunohistochemistry demonstrated that congestions and inflammatory responses in liver and lung were markedly ameliorated by PEO. Conclusions: Our results demonstrated that PEO infusion could effectively improve microcirculation after hemorrhagic shock and increase the chance of survival in animal models.

【 授权许可】

Unknown