期刊论文详细信息
International Journal of Clinical and Experimental Medicine | |
Detection of pulmonary metastases with the novel radiolabeled molecular probe, 99mTc-RRL | |
Ning Yao1  Chun-Li Zhang1  Chao Ma1  Ping Yan1  Pan Hao1  Qian Zhao1  Xue-Qi Chen1  Rong-Fu Wang1  | |
关键词: 99mTc; peptide; tumor angiogenesis; lung metastasis; non-invasive imaging; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Background: To improve the detection of pulmonary metastases, experimental blood-borne pulmonary metastasis mouse models were established using three intravenously administered cell lines. In a previous study we demonstrated that 99mTc-radiolabeled arginine-arginine-leucine (RRL) could be used to non-invasively image malignant tumors. Methods: 99mTc-RRL was prepared and injected intravenously in mice with pulmonary metastases that arose from the intravenous injection of HepG2, B16, and Hela cells. The bio-distribution and imaging of 99mTc-RRL were determined in different pulmonary metastases mouse models and in normal mice. Results: 99mTc-RRL exhibited higher uptake values in the lungs of pulmonary metastatic mice compared to normal mice (P<0.05; 3.92±0.48% ID/g 2 h post-injection and 3.89±0.36% ID/g 4 h post-injection in metastatic hepatic carcinoma [HepG2]-bearing lungs; 5.49±0.84% ID/g 2 h post-injection and 5.11±0.75% ID/g 4 h post-injection in metastatic melanoma [B16]-bearing lungs; 3.72±0.52% ID/g 2 h post-injection and 3.51±0.35% ID/g 4 h post-injection in metastatic cervical carcinoma [Hela]-bearing lungs; 2.38±0.20% ID/g 2 h post-injection and 2.11±0.24% ID/g 4 h post-injection in normal lungs). The pulmonary metastatic lesions were clearly visualized using 99mTc-RRL. Conclusions: 99mTc-RRL exhibited favorable metastatic tumor targeting and imaging properties, thus highlighting its potential as an effective imaging probe for detection of pulmonary metastases. 99mTc-RRL can be used as a reasonable supplement to 18F-FDG imaging in the non-invasive imaging of tumor angiogenesis.【 授权许可】
Unknown
【 预 览 】
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