Effects of fermentable dietary fiber supplementation on oxidative and inflammatory status in hemodialysis patients

International Journal of Clinical and Experimental Medicine

Yi-Qiong Zhang¹  Jun-Xuan Li¹  Liang-Min Xie¹  Yi-Yun Ge¹  Xin Huang¹ 

关键词: Dietary fiber;    hemodialysis;    inflammation;    oxidative status;    blood lipids;    cardiovascular disease;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Background: Increased oxidative stress, inflammation, and malnutrition are important risk factors for cardiovascular disease in hemodialysis patients. High dietary intake in soluble fiber can decrease the elevated level of serum c-reactive protein in patients with chronic kidney disease. The aim of this study was to evaluate the effect of supplementation of dietary water-soluble fiber on oxidative and inflammatory status in hemodialysis patients. Methods: In a randomized placebo-controlled trial, we examined the effects of supplementation of dietary fiber on oxidative and inflammatory status in hemodialysis patients. 124 hemodialysis patients were randomly selected and given either 10 g/d, 20 g/d of fiber or placebo for 6 weeks. Anthropometric indices and 24 h diet recall intake was assessed. The CRP, albumin, triglyceride, total cholesterol, LDL, HDL were measured before and after of the intervention. The malondialdehyde (MDA), total antioxidant capacity (T-AOC), Cu-Zn superoxidase dismutase (SOD), glutathione peroxidase (GSH-Px) high-sensitivity C-Reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) were measured. Results: After 6 weeks of intervention, in 10 g and 20 g/d of fiber supplement groups, TC and LDL level and TC:LDL ratio were significantly decreased, T-AOC was significantly increased, MDA level was significantly deceased, TNF-α, IL-6, IL-8 and CRP level were significantly deceased. TG, HDL, SOD and GSH-Px had no change before and after the intervention. Conclusions: Dietary fermentable fiber supplementation improved lipid profile and oxidative status, decreased systemic inflammatory state of hemodialysis patients. Thus, it may decrease the risk of cardiovascular events in these patients.

【 授权许可】

Unknown