PIAS3, an inhibitor of STAT3, has intensively negative association with the survival of gastric cancer

International Journal of Clinical and Experimental Medicine

Longcai Han¹  Chunliang Jia¹  Jingwu Li¹  Yuanting Liu¹  Jianzhong Cui¹  Jinghua Zhang¹  Han Liang¹  Jingyu Deng¹ 

关键词: Stomach;    neoplasm;    protein inhibitor of activated signal transducer and activators of transcription 3;    survival;    lymph node;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: The present study was conducted to elucidate the prognostic prediction value of the expression of the protein inhibitor of activated signal transducer and activators of transcription 3 (PIAS3) in gastric cancer (GC). Methods: We detected the expression of PIAS3 in GC tissue, adjacent non-tumor tissue, GC cell lines, and GES-1 cell line. Besides, both clinicopathological data and follow-up records were obtained for patients’ survival analyses. Results: We showed that both protein and mRNA expression of PIAS3 in GC tissue were significantly lower than those in adjacent non-tumor tissue, respectively. Besides, the relative mRNA expression value of PIAS3 in each of GC cell lines was also much lower than that in GES-1 cell line. With multivariate survival analyses, PIAS3 protein expression in GC tissues, and status of lymph node metastasis were identified to be the independently prognostic predictors of GC by using the Cox regression with bootstrapping method. Conclusions: Lower expression of PIAS3 protein, indicating the poor survival of GC, is a potential marker for prediction the prognosis of patients.

【 授权许可】

Unknown