Mutant of leucine-rich repeat kinase 2 is not associated with non-motor symptoms in Chinese Parkinson’s disease patients

International Journal of Clinical and Experimental Medicine

Xiaohong Wang¹  Qinghua Zhang¹  Ning Pan¹  Maolin Hao¹ 

关键词: LRRK2 variants;    on-motor symptoms;    NMS Quest;    nocturia;    Parkinson’s disease;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Non-motor symptoms (NMS) are common in patients with Parkinson’s disease (PD). However, little is known about NMS in patients with mutant of leucine-rich repeat kinase 2 (LRRK2). This study aimed to elucidate the relationship between NMS in Chinese PD patients and to ascertain if there were differences in NMS between PD patients and mutant of LRRK2. 200 sporadic PD (sPD) patients were recruited from a Provincial Hospital Affiliated to Shandong University. The Non-motor Symptom Questionnaire (NMSQ) was used to screen for the presence of NMS. A mean of 9.73 NMS (SD=4.53) was reported per patient. Forgetfulness, constipation and daytime sleepiness were found to be the most frequent NMS. No differences were found in 9 domains analysis between PD with and without LRRK2 variants. Non-motor symptoms in PD are too important to remain undetected. There are no Clinical characteristics of NMS tend to be similar between LRRK2 variants carriers and non-carriers in Chinese sPD patients.

【 授权许可】

Unknown