Coagulation parameters in inflammatory bowel disease

International Journal of Clinical and Experimental Medicine

Can Dolapcioglu¹  Sevim Purisa¹  Remzi Dalay¹  Aliye Soylu¹  Hatice Dolapcioglu¹  Haci Mehmet Sokmen¹  Ali Tuzun Ince¹  Tulin Kendir¹  Cengiz Bolukbas¹  Oya Ovunc¹ 

关键词: Inflammatory bowel disease (IBD);    ulcerative colitis;    Crohn’s disease;    coagulation;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Thromboembolic events represent a major cause of morbidity and mortality in patients with inflammatory bowel disease and they may occur both at the gastrointestinal tract and at extraintestinal sites. This study aimed to examine the alterations in coagulation parameters involved at different steps of hemostasis in patients with Crohn’s disease and ulcerative colitis, in comparison with healthy individuals. Fifty-one patients with inflammatory bowel disease and 26 healthy controls were included in this study. Plasma levels of PT, APTT, AT III, plasminogen, fibrinogen, D-dimer, factor V, factor VIII, protein C, protein S, and APCR were measured and factor V Leiden mutation was examined in both patients and controls. Two patients with ulcerative colitis had a history of previous thromboembolic event. Inflammatory bowel disease was associated with significantly higher levels of fibrinogen, PT, factor V, factor VIII, plasminogen and thrombocyte. Protein S, fibrinogen, plasminogen and thrombocyte levels were associated with disease activity, depending on the type of the disease (Crohn’s disease or ulcerative colitis). The coagulation abnormalities detected in this study seems to be a secondary phenomena resulting from the disease process, which is more likely to be associated with a multitude of factors rather than a single abnormality.

【 授权许可】

Unknown