Association between TGF-β1 +869C/T polymorphism and fracture risk: a meta-analysis

International Journal of Clinical and Experimental Medicine

Tao Zhang¹  Zhi-Chang Zhang¹  Neng-Bin He¹ 

关键词: Fracture;    TGF-β1;    meta-analysis;    polymorphism;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

The association between TGF-β1 +869C/T polymorphism and risk of fractures remained controversial. Therefore, we performed this meta-analysis to investigate this association. We searched PubMed, EMBASE, and Wangfang databases for studies before Aug 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. A total of ten studies were included in this meta-analysis. TGF-β1 +869C/T polymorphism was associated with a significantly increased risk of fracture (OR=1.41; 95% CI, 1.20-1.65; I²=0%). In the subgroup analysis according to gender, women was significantly associated with risk of fracture (OR=1.44; 95% CI, 1.20-1.73; I²=4%). In the subgroup analysis by race, Asians (OR=1.43; 95% CI, 1.06-1.92; I²=0%) and Caucasians (OR=1.44; 95% CI, 1.13-1.85; I²=15%) showed increased fracture risk. Our meta-analysis suggested that the TGF-β1 +869C/T polymorphism may be a risk factor for developing fracture.

【 授权许可】

Unknown