Effect of adenoviral delivery of prodynorphin gene on experimental inflammatory pain induced by formalin in rats

International Journal of Clinical and Experimental Medicine

Tingting Wang¹  Baihong Chen¹  Xionggang Chen¹  Caizhu Lin¹ 

关键词: Adenoviral delivery;    prodynorphin;    dynorphin A;    formalin;    hyperalgesia;    spinal dorsal horn;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Circumstantial evidences suggest that dynorphins and their common precursor prodynorphin (PDYN) are involved in antinociception and neuroendocrine signaling. DREAM knockout mice had increased levels of PDYN and dynorphin expression, and reduced sensitivity to painful stimuli. However, some data support the notion that the up-regulation of spinal dynorphin expression is a common critical feature in neuropathic pain. It is not clear whether the production of dynorphin A can be increased when more PDYN is present. In this study we investigated the changes in pain behaviors, spinal PDYN mRNA expression and dynorphin A production on formalin-induced pain in rats receiving the pretreatment of adenoviral delivery of PDYN. Our results showed that the adenoviral transfer of PDYN gene was sufficient to reduce pain behaviors resulting from formalin injection, and the antinociceptive effect after receiving the pretreatment of adenoviral delivery of PDYN was mediated at the level of the spinal cord via KOR.

【 授权许可】

Unknown