Effect of cold adaptation on activities of relevant enzymes and antioxidant system in rats

International Journal of Clinical and Experimental Medicine

Jian-Feng Chen¹  Ji-Qing Xing¹  Wei Fang¹  Shang-Bin Li¹  Yang Zhou¹  Jun Yang¹ 

关键词: Cold adaptation;    adenylate cyclase;    phosphodiesterase;    Na+·K+ ATPase;    malondialdehyde;    superoxide dismutase;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Exercise in cold environments can cause significant metabolic regulation and antioxidant behavior. For discussing enzymatic responses towards cold adaptation, we investigated enzyme activities of adenylate cyclase (AC) and phosphodiesterase (PDE) in liver, skeletal muscle, and brown adipose tissue (BAT), as well as Na⁺·K⁺ ATPase and Na⁺/K⁺ ratio in blood. Malondialdehyde (MDA) and superoxide dismutase (SOD) activity in blood were also studied to address the effect of cold adaptation on oxidative damage and antioxidant system. Experimental results indicated that enzyme activities in liver, skeletal muscle and BAT maintained relatively constant for the control group. For the cold adaptation group, enzyme activities in liver and skeletal muscle were in high levels at the beginning, and then gradually decreased to similar values with the control group. However, enzyme activities in BAT performed an increasing trend and significantly higher than the control at the end. In addition, decreased oxidative damage and activated antioxidant system was observed along with the cold adaptation process.

【 授权许可】

Unknown