International Journal of Clinical and Experimental Medicine | |
Changes of acute-phase protein levels in the serum of lung cancer patients following radiotherapy | |
Kouloulias E Vasileios1  Pantelakos S Panagiotis1  Tolia G Maria1  Syrigos N Kostas1  | |
关键词: Acute phase proteins; lung cancer; radiotherapy; | |
DOI : | |
学科分类:医学(综合) | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Purpose: the assessment of serum level changes of C-reactive protein (CRP), ferritin (FER), and albumin (ALB) as inflammation markers in Non Small Cell Lung Cancer patients (stages IIIA - inoperable and stage IIIB) treated with radiotherapy. Significant findings: Normal pre-radiotherapy levels of CRP were found in 18 patients, of FER in 17, and of ALB in 22. Higher levels of CRP were found in 9 patients and of FER in 10. Lower ALB was found in 5 patients.Post-radiotherapy CRP levels were significantly higher (compared to the pre-radiotherapy levels) in 25 patients. The same was observed regarding FER in 18 patients whereas 12 patients had lower post-radiotherapy levels. The statistical analysis (non parametrical Wilcoxon test) revealed that these differences were statistically significant (p-value< 0.001). Conclusions: The levels of CRP, FER, and ALB are reliable and useful biomarkers correlated with the acute complication of lung parenchyma damage induced by radiotherapy.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912140863526ZK.pdf | 127KB | download |