68Ga-DotaTATE PET-CT followed by Peptide Receptor Radiotherapy in combination with capecitabine in two patients with Merkel Cell Carcinoma

International Journal of Clinical and Experimental Medicine

Max Schlaak¹  Sabine Kunze¹  Richard P Baum¹  Markus Dietlein¹  Birgit Cremer¹  Matthias C Schmidt¹  Birgid Markiefka¹  Klara Uhrhan¹  Laura Hasselbring¹ 

关键词: Merkel cell carcinoma (MCC);    PET-CT;    68Ga-DotaTATE;    90Y-DotaTATE;    177Lu-DotaTATE;    Peptide Receptor Radiotherapy (PRRT);    Theranostic;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Herein, we report about two Caucasian patients with the histopathological diagnosis of Merkel cell carcinoma suffering from extensive lymph node metastases. The extent of the disease was diagnosed by Ga-68-DotaTATE-PET-CT. Both patients had rapid disease progression, one of them despite a three months course of sunitinibe followed by four chemotherapy cycles of cisplatin and etoposide. Both patients were sent for peptide receptor radiotherapy with 90Y-DotaTATE or 177Lu-DotaTATE in combination with capecitabine. Additional external beam radiotherapy of the cervical and inguinal lymph nodes was given to the patient with progressive disease despite chemotherapy. Temporary partial response in both patients was achieved. Despite extensive therapeutic efforts, fatal outcome could not be prevented 10 and 14 months after first clinical symptoms.

【 授权许可】

Unknown