Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers

International Journal of Biochemistry and Molecular Biology

Hailan Li¹  Youyun Yang¹  C. Max Schmidt¹  Liang Cheng¹  Zhaomin Li¹  Michelle Yip-Schneider¹  Jingwu Xie¹  E. Gabriela Chiorean¹  Jey-Hsin Chen¹  Jian-Ting Zhang¹  Zijin Zhao¹  Qipeng Fan¹ 

关键词: Human fatty acid synthase (FASN);    palmitate;    gemcitabine;    radiation treatments;    treatment resistance;    pancreatic cancers;   

DOI  :  

学科分类：生物化学/生物物理

来源: e-Century Publishing Corporation

【 摘 要 】

Human fatty acid synthase (FASN) is a homo-dimeric protein with multi-enzymatic activity responsible for the synthesis of palmitate. FASN expression has been found to be up-regulated in multiple types of human cancers and its expression correlates with poor prognosis possibly by causing treatment resistance. In this study, we tested if FASN expression is up-regulated in human pancreatic cancers and if its higher expression level in pancreatic cancers causes intrinsic resistance to gemcitabine and radiation. We found that FASN expression is significantly up-regulated in human pancreatic cancer tissues without any correlation to age, sex, race, and tumor stage. Knocking down or over-expressing FASN significantly down- or up-regulate resistance of pancreatic cancer cell lines to both gemcitabine and radiation treatments. These findings imply that the elevated FASN expression in pancreatic cancers may contribute to unsuccessful treatments of pancreatic cancers by causing intrinsic resistance to both chemotherapy and radiation therapy.

【 授权许可】

Unknown