Towards bridging the gap between acid-base transporters and neuronal excitability modulation

International Journal of Physiology, Pathophysiology and Pharmacology

Ying Liu¹  Li-Ming Chen¹ 

关键词: SLC4 family;    SLC9;    bicarbonate transporter;    NDCBE;    NHE3;    acid-base balance;    pH regulation;    neuronal excitability;    neuron;    KCNQ;    Kv7;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

pH homeostasis is a fundamental regulator of the function of the central nervous system. Dysfunction of acid-base transporters often results in disturbance of neuronal excitability. In a latest issue of Journal of Neuroscience, Jones et al. report that increasing intracellular bicarbonate concentration substantially stimulates the excitability of pyramidal neurons from mouse hippocampus by inhibiting KCNQ potassium channel. The finding shed important new light in understanding the molecular mechanism underlying the regulation of neuronal excitability by acid-base transporters.

【 授权许可】

Unknown