P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control

International Journal of Physiology, Pathophysiology and Pharmacology

Miguel Diaz-Hernandez¹  David C Henshall¹  Tobias Engel¹  Maria Teresa Miras-Portugal¹  Alba Jimenez-Pacheco¹ 

关键词: Adenosine 5’-triphosphate;    anticonvulsant;    epilepsy;    hippocampal sclerosis;    interleukin 1 beta;    status epilepticus;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively expressed in neurons and glia in the brain. Activation of the P2X7 receptor has been found to modulate neuronal excitability in the hippocampus and it has also been linked to microglia activation and neuroinflammatory responses. Accordingly, interest developed on the P2X7 receptor in disorders of the nervous system, including epilepsy. Studies show that expression of the P2X7 receptor is elevated in damaged regions of the brain after prolonged seizures (status epilepticus) in both neurons and glia. P2X7 receptor expression is also increased in the hippocampus in experimental epilepsy. Recent data show that mice lacking the P2X7 receptor display altered susceptibility to status epilepticus and that drugs targeting the P2X7 receptor have potent anticonvulsant effects. Together, this suggests that P2X7 receptor ligands may be useful adjunctive treatments for refractory status epilepticus or perhaps pharmacoresistant epilepsy. This review summarizes the evidence of P2X7 receptor involvement in the pathophysiology of epilepsy and the potential of drugs targeting this receptor for seizure control.

【 授权许可】

Unknown