Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists

International Journal of Physiology, Pathophysiology and Pharmacology

Stephen C Land¹ 

关键词: α-melanocyte stimulating hormone-derived tripeptide;    KPV;    melanocortin receptor;    MC3R;    γ-melanocyte stimulating hormone (γ-MSH);    airway epithelium;    chemokine signaling;    asthma;    inflammation;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Chemokine signaling from airway epithelium regulates macrophage recruitment to the lung in inflammatory diseases such as asthma. This study investigates the mechanism by which the α-melanocyte stimulating hormone-derived tripeptide, KPV, and the agonist of the dominant melanocortin receptor in airway epithelium (MC3R), γ-melanocyte stimulating hormone (γ-MSH), suppress inflammation in immortalised human bronchial airway epithelium.

【 授权许可】

Unknown