Prognostic significance of IDH1 mutations in acute myeloid leukemia: a meta-analysis

American Journal of Blood Research

Zhu-Jun Wang¹  Yuan-Yuan Chen¹  Jian-Hua Feng¹  Yong-Min Tang¹  Yu-Ping Cheng¹  Xiao-Ping Guo¹ 

关键词: Acute myeloid leukemia;    IDH1;    mutation;    prognosis;    meta-analysis;   

DOI  :  

学科分类：血液学

来源: e-Century Publishing Corporation

【 摘 要 】

Isocitrate dehydrogenase 1 (IDH1) gene aberrations have recently been reported in acute myeloid leukemia (AML). To evaluate the prognostic significance of IDH1 mutations in AML, we performed a meta-analysis. Fifteen studies covering a total of 8121 subjects were included in this analysis. The frequency of IDH1 R132 mutations were 4.4–9.3% for AML patients and 10.9–16.0% for cytogenetically normal (CN)-AML patients. The IDH1 mutations were associated with NPM1 mutations in 6 studies and normal cytogenetics in 5 studies. AML patients with IDH1 mutations had inferior overall survival compared to patients without the mutations (hazard ratio 1.17, 95% CI: 1.02–1.36). Additionally, in CN-AML patients, IDH1 mutations were associated with a lower complete remission rate (risk ratio 1.30, 95% CI: 1.04–1.63). Although the available literature is limited to observational studies, these results may justify the risk-adapted therapeutic strategies for AML according to the IDH1 status.

【 授权许可】

Unknown