A long road of T-cells to cure cancer: from adoptive immunotherapy with unspecific cellular products to donor lymphocyte infusions and transfer of engineered tumor-specific T-cells

American Journal of Blood Research

Maria Liga¹  Alexandros Spyridonidis¹ 

关键词: Immunocompetent cells;    antitumor effect;    T-cell immunotherapy;    allogeneic bone marrow transplantation;    tumor-specific T-cells;   

DOI  :  

学科分类：血液学

来源: e-Century Publishing Corporation

【 摘 要 】

The notion that immunocompetent cells, contained within adult bone marrow or peripheral blood, are capable of mediating an antitumor effect was first validated experimentally in 1957. T-cell immunotherapy for malignant disease is now routinely used in the context of allogeneic bone marrow transplantation. After 50 years of investigations into the use of T-cells for cancer therapy, adoptive cellular immunotherapy for cancer has progressed from the delivery of unspecific cellular products to the transfer of engineered tumor-specific T-cells. Adoptive cellular immunotherapy for cancer has now reached a stage of increasing feasibility and efficacy.

【 授权许可】

Unknown