Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology

American Journal of Blood Research

Tamisha Y Vaughan¹  Sheetal Verma¹  Kevin D Bunting¹ 

关键词: Adapter protein;    cytokine signaling;    Grb2-associated binding protein;    Gab;    receptor tyrosine kinase;    cancer signaling;   

DOI  :  

学科分类：血液学

来源: e-Century Publishing Corporation

【 摘 要 】

Grb2-associated binding (Gab) scaffolding/adapter proteins are a family of three members including mammalian Gab1, Gab2, and Gab3 that are highly conserved. Since the discovery of these proteins, there has been an extensive amount of work done to better understand Gab functional roles in multiple signaling pathways, typically acting as a downstream effectors of receptor-tyrosine kinase (RTK)-triggered signal transduction. In addition to their participation in hematopoiesis, Gabs play important roles in regulation of immune response and in also in cancer cell signaling. Gabs may play complex roles and thus a complete understanding of their interactions and how they modulate hematopoietic and immune cell biology remains to be determined. This review will cover the most recent findings including the involvement of Gabs in disease development and signaling which will be important for design of future therapeutic interventions.

【 授权许可】

Unknown