Specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia

American Journal of Blood Research

Karim Maloum¹  Benoit Quilichini¹  Florence Nguyen-Khac¹  Claude Lesty¹  Virginie Eclache¹  Catherine Settegrana¹  Hélène Merle-Béral¹  Elise Chapiro¹  Isabelle Luquet¹  Victoria Raggueneau¹  Francine Mugneret¹  Marie-Agnes Collonge-Rame¹  Isabelle Radford-Weiss¹  Nathalie Gachard¹  Steven Richebourg¹  Evelyne Callet-Bauchu¹  Lucienne Michaux¹  Stéphanie Struski¹  Sylvie Taviaux¹  Carole Barin¹  Nicole Dastugue¹  Carine Gervais¹  Eric Lippert¹  Laurence Baranger¹  Pascaline Talmant¹  Christine Lefebvre¹  Sandra Fert-Ferrer¹  Aurore Grelier¹  Frederic Davi¹ 

关键词: Chronic lymphocytic leukemia;    IGH;    BCL2;    chromosomal translocation;   

DOI  :  

学科分类：血液学

来源: e-Century Publishing Corporation

【 摘 要 】

Chromosomal translocations are usually analyzed as a single entity, and are associated with a poor outcome in chronic lymphocytic leukemia. Translocations involving immunoglobulin genes are recurrent, but uncommon (<5%), and their individual prognosis is not clear. The two most frequent partners are BCL2 (18q21) and BCL3 (19q13).

【 授权许可】

Unknown