MicroRNAs in ischemia-reperfusion injury

American Journal of Cardiovascular Disease

Steffen U Eisenhardt¹  Christoph Bode¹  Sebastian Grundmann¹  G Björn Stark¹  Martin Moser¹  Jakob BW Weiss¹ 

关键词: MicroRNA;    ischemia-reperfusion injury;    inflammation;    acute myocardial infarction;    revascularization;   

DOI  :  

学科分类：心脏病和心血管学

来源: e-Century Publishing Corporation

【 摘 要 】

Ischemia-reperfusion injury (IRI) is a major causal factor of tissue injury in various clinical settings including myocardial infarction, stroke, and free microsurgical tissue transfer. MicroRNAs (miRNAs, miRs) are short, non-coding RNA molecules involved in post-transcriptional regulation of gene expression. During the last years they have emerged as regulators of IRI as well as ischemic preconditioning and ischemic postconditioning. Here we give an overview of the current literature and describe the potential use of miRNA-based therapeutics for the treatment and prevention of ischemia-reperfusion injury in the future.

【 授权许可】

Unknown