Relationship between pretreatment FDG-PET and diffusion-weighted MRI biomarkers in diffuse large B-cell lymphoma

American Journal of Nuclear Medicine and Molecular Imaging

Otto S Hoekstra¹  Jaap Stoker¹  Marie José Kersten¹  Josée M Zijlstra¹  Indra C Pieters - Van den Bos¹  Inge Ludwig¹  Bart de Keizer¹  John MH de Klerk¹  Antoinette de Jong¹  Rob Fijnheer¹  Thomas C Kwee¹  Yvonne WS Jauw¹  Judit A Adam¹  Rutger AJ Nievelstein¹ 

关键词: FDG-PET;    diffusion-weighted MRI;    standardized uptake value;    apparent diffusion coefficient;    diffuse large B-cell lymphoma;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

The purpose of this study was to determine the correlation between the ¹⁸F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) standardized uptake value (SUV) and the diffusion-weighted magnetic resonance imaging (MRI) apparent diffusion coefficient (ADC) in newly diagnosed diffuse large B-cell lymphoma (DLBCL). Pretreatment FDG-PET and diffusion-weighted MRI of 21 patients with histologically proven DLBCL were prospectively analyzed. In each patient, maximum, mean and peak standardized uptake value (SUV) was measured in the lesion with visually highest FDG uptake and in the largest lesion. Mean ADC (ADC_mean, calculated with b-values of 0 and 1000 s/mm²) was measured in the same lesions. Correlations between FDG-PET metrics (SUV_max, SUV_mean, SUV_peak) and ADC_mean were assessed using Pearson’s correlation coefficients. In the lesions with visually highest FDG uptake, no significant correlations were found between the SUV_max, SUV_mean, SUV_peak and the ADC_mean (P=0.498, P=0.609 and P=0.595, respectively). In the largest lesions, there were no significant correlations either between the SUV_max, SUV_mean, SUV_peak and the ADC_mean (P=0.992, P=0.843 and P=0.894, respectively). The results of this study indicate that the glycolytic rate as measured by FDG-PET and changes in water compartmentalization and water diffusion as measured by the ADC are independent biological phenomena in newly diagnosed DLBCL. Further studies are warranted to assess the complementary roles of these different imaging biomarkers in the evaluation and follow-up of DLBCL.

【 授权许可】

Unknown