FIAU: From reporter gene imaging to imaging of bacterial proliferation

American Journal of Nuclear Medicine and Molecular Imaging

Peter Laverman¹  Otto C Boerman¹  Wim JG Oyen¹ 

关键词: Infection;    inflammation;    reporter gene imaging;    positron emission tomography (PET);   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

The radioiodinated thymidine analogue, FIAU, is a tracer that has been developed for reporter gene, for cells that were transfected with herpes simplex virus thymidine kinase, HSV-TK. FIAU is also a specific substrate of bacterial TK due to the homology between viral and bacterial TK. In this issue of AJNMMI (http://www.ajnmmi.us), Pullamb-hatla et al. reported that the accumulation of ¹²⁵I-FIAU in pulmonary infectious foci correlated with the bacterial burden in the lungs. ¹²⁵I-FIAU could be used to monitor the efficacy of anti-microbial therapy in mice. Potentially ¹²⁴I-FIAU PET could be used to discriminate microbial from sterile inflammation in patients with prosthetic implants.

【 授权许可】

Unknown