PET imaging of metabotropic glutamate receptor subtype 5 (mGluR5)

American Journal of Nuclear Medicine and Molecular Imaging

Peter Conti¹  Zibo Li¹  Dan Li¹  Hong Shan¹ 

关键词: mGluR5;    positron emission tomography (PET);    18F;    11C;    molecular imaging;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Metabotropic glutamate receptors (mGluRs) belong to a family of G-protein coupled receptors involved in the modulation of fast excitatory transmission. In particular, the subtype-5 receptor (mGluR5) was found to be an attractive target for the treatment and diagnosis of variety of psychiatric and neurological disease including anxiety, depression, epilepsy, drug addiction, and Parkinson's disease. Positron emission tomography (PET) is a highly sensitive imaging technique that holds great potential for the diagnosis of a brain disorder. In the study published in the American Journal of Nuclear Medicine and Molecular Imaging, a ¹⁸F labelled PET probe was developed targeting mGluR5. This paper represents the efforts and challenges on the design and development of novel PET tracers for mGluR5 imaging.

【 授权许可】

Unknown