Estrogen receptors in prostate development and cancer

American Journal of Clinical and Experimental Urology

Jun Da¹  Wenbin Song¹  Chiuan-Ren Yeh¹  Anees Fazili¹  Shuyuan Yeh¹ 

关键词: Estrogen receptor;    environment estrogen;    prostate cancer;    SERM;    tissue specific ERα knockout mouse;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Prostate cancer (PCa) is an androgen-sensitive disease, which can be pharmacologically controlled by androgen blockade. To date, a growing body of evidence showed that estrogen and estrogen receptors (ERs) could regulate prostate development, as well as cancer initiation and progression. This review will address the expression levels and function of ERs in different stages of PCa progression. The functions of ERs in different types of prostate cells, the ligand effect, and the potential applications of selective estrogen modulators (SERMs) will also be discussed. To further dissect ERs’ roles in prostate development, cell type specific ER knockout mouse models were generated. Results collected from the prostate cell type-specific ERαKO mouse models provided new insights about the cell type specific ERα roles in prostate development prenatally and postnatally. The results of ERs’ roles in mouse PCa mode and the correlation of ERs expression and biomedical outcome will also be discussed.

【 授权许可】

Unknown