Metastasis as a therapeutic target in prostate cancer: a conceptual framework

American Journal of Clinical and Experimental Urology

Andries Zijlstra¹  Katie Hebron¹  Srijan Raha¹  Konstantin Stoletov¹  David Bond¹  John D Lewis¹ 

关键词: Metastasis;    prostate cancer;    molecular targets and biomarkers of metastasis;    clinical trial design;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Metastasis is the main cause of prostate cancer-associated deaths. While significant progress has been made in the treatment of primary tumors, efficient therapies that target the metastatic spread of prostate cancer are far from clinical reality. To efficiently treat cancer we need be able to impede its spread. Unfortunately, the majority of current therapeutics approved to treat metastatic cancer were originally selected based on their ability to inhibit primary tumor growth. This inherent flaw precludes these therapies from efficiently targeting the development of secondary metastatic lesions, a process that is distinct from that of primary tumor progression. In this review we will summarize the conceptual, cellular and molecular targets that should be considered to design effective anti-metastatic therapies.

【 授权许可】

Unknown