Effect of Kelussia odoratissima Mozaffarian on Lipid and Glucose Profile

lranian journal of Clinical Infectious Diseases

Parto Nasri³  Azam Asgari¹  Zahra Abedi Gheshlaghi²  Neda Parvin¹  Hedayatollah Shirzad¹  Mehrdad Shahrani¹  Mahmoud Rafieian Kopaei¹ 

[1] Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IR Iran;Nickan Research Institute, Isfahan, IR Iran;Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran

关键词: Hyperlipidemia;    Mice;    Human;    Triglyceride;    Cholesterol;   

DOI  :  10.17795/semj29662

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background:Flavonoidsareagroupofpolyphenoliccompoundswithantioxidantpropertiesthathelpreducecardiovascularriskfactors.Kelussiaodoratissimaisaflavonoid-containingplant,theeffectofwhichwasanalyzedondecreasingbloodlipidlevelsinmice.Objectives:Thepresentstudywascarriedoutwiththeaimofdeterminingtheanti-hyperlipidemiaeffectsofthisherbonmice.MaterialsandMethods:Inthispreclinicalstudy,70Balb/cmiceweredividedtofive14-membergroupsandreceivednormaldiet,normaldietcontaining5%oliveoil,highcholesterol(2%cholesteroland5%oliveoil)dietandhighcholesteroldietaccompaniedbyKelussiaodoratissima10%or20%hydro-alcoholicextract.Aftertwoweeks,bloodsamplesweretakenandcholesterol,triglyceride,lowdensitylipoprotein(LDL),verylowdensitylipoprotein(VLDL),highdensitylipoprotein(HDL),andfastingbloodsugar(FBS)weremeasured.Results:Inthisanimalmodel,thelevelsofallserumlipidsincludingcholesterol,HDL,VLDL,LDL,triglycerideandFBShadasignificantdecreasetwoweeksafterthebeginningofthestudy.Moreover,atthesametime,inthegroupthatreceived20%hydro-alcoholicextract,theserumlevelsofcholesterol,HDLandLDLhadasignificantdecrease(Plt;0.05).Conclusions:Kelussiaodoratissimamighthaveadesirableeffectonserumlipidprofileandmighthavebeneficialeffectsonhyperlipidemicpatients.

【 授权许可】

Unknown