The Effect of Intravenous Midazolam on Duration of Spinal Anesthesia

lranian journal of Clinical Infectious Diseases

Ameneh Alikhani¹  Mitra Jabalameli²  Zahra Amini¹  Mohammad Golparvar¹  Mehran Rezvani²  Reihanak Talakoub² 

[1] Isfahan University of Medical Sciences, Isfahan, IR Iran;Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, IR Iran

关键词: Anesthesia;    Spinal;    Midazolam;    Intravenous Injection;   

DOI  :  10.17795/semj21586

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background:Avarietyofsystemicandintrathecaladjuvantstolocalanestheticshavebeenfoundtoexpandthedurationandimprovethequalityofspinalblockanddecreasepainaftersurgeries.Objectives:Theaimofthisstudywastoevaluatetheeffectoftheadditionofmidazolamtolidocaineforspinalanesthesiainlowerabdomenandlowerlimbsurgeries.PatientsandMethods:Inaprospective,randomized,doubleblindstudy,36patientsaged20to60years,andAmericanSocietyofAnesthesiologists(ASA)IorII,wererandomlyallocatedtoreceiveeitherintravenousmidazolam(30μg/kg)orplaceboinspinalanesthesia.Levelofsensoryblock,timetoachievemaximummotorandsensoryblock,durationofsensoryandmotorblock,recoverytime,sideeffects,heartrate,bloodpressure,arterialoxygensaturationandsedationscoreweremeasuredandanalyzedusingtheSPSSsoftwareversion15byt-testandANOVA.Datawereconsideredsignificantat0.05.Results:Themotorblockdurationinmidazolamandcontrolgroupwas82.9±27.3and59.1±26.5,respectively(P=0.01).Howeverthedurationofsensoryblockwasnotdifferentbetweenthetwogroups(P=0.07).ThemedianofsensoryblocklevelwasatT8andT10inmidazolamandcontrolgroup(P=0.02).Recoverytimewasmoreprolongedinthemidazolamgroup(P=0.002).Hemodynamicindicesdidnotshowanysignificantdifferencesbetweenthetwogroups.Conclusions:Additionof30μg/kgmidazolamtolidocaineforspinalanesthesiaimproveddurationofmotorblockandincreasedintraoperativesedationscorewithoutcausingsideeffectsinpatients’requiringlowerabdomenandlowerlimbsurgery.

【 授权许可】

Unknown